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Target
Sphingosine 1-phosphate receptor 3
Ligand
BDBM50158345
Substrate
n/a
Meas. Tech.
ChEMBL_799914 (CHEMBL1941620)
EC50
>25000±n/a nM
Citation
 Pennington, LD; Croghan, MD; Sham, KK; Pickrell, AJ; Harrington, PE; Frohn, MJ; Lanman, BA; Reed, AB; Lee, MR; Xu, H; McElvain, M; Xu, Y; Zhang, X; Fiorino, M; Horner, M; Morrison, HG; Arnett, HA; Fotsch, C; Tasker, AS; Wong, M; Cee, VJ Quinolinone-based agonists of S1P¿?: use of a N-scan SAR strategy to optimize in vitro and in vivo activity. Bioorg Med Chem Lett 22:527-31 (2011) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 3
Synonyms:
C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42278.13
Organism:
Homo sapiens (Human)
Description:
Q99500
Residue:
378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
  
Inhibitor
Name:
BDBM50158345
Synonyms:
5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole | CHEMBL224720
Type:
Small organic molecule
Emp. Form.:
C20H10F6N2OS
Mol. Mass.:
440.362
SMILES:
FC(F)(F)c1sc(cc1-c1ccccc1)-c1nc(no1)-c1cccc(c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: