Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50363174
Substrate
n/a
Meas. Tech.
ChEMBL_800433 (CHEMBL1948454)
Ki
39±n/a nM
Citation
 Hou, X; Majik, MS; Kim, K; Pyee, Y; Lee, Y; Alexander, V; Chung, HJ; Lee, HW; Chandra, G; Lee, JH; Park, SG; Choi, WJ; Kim, HO; Phan, K; Gao, ZG; Jacobson, KA; Choi, S; Lee, SK; Jeong, LS Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A2A and A3 adenosine receptor ligands. J Med Chem 55:342-56 (2012) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50363174
Synonyms:
CHEMBL1946297
Type:
Small organic molecule
Emp. Form.:
C22H24IN5O2S
Mol. Mass.:
549.428
SMILES:
CCCCC#Cc1nc(NCc2cccc(I)c2)c2ncn([C@@H]3SC[C@@H](O)[C@H]3O)c2n1 |r|
Structure:
Search PDB for entries with ligand similarity: