Target
Bifunctional protein GlmU
Ligand
BDBM50365095
Substrate
n/a
Meas. Tech.
ChEMBL_804877 (CHEMBL1953925)
IC50
500±n/a nM
Citation
 Green, OMMcKenzie, ARShapiro, ABOtterbein, LNi, HPatten, AStokes, SAlbert, RKawatkar, SBreed, J Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series. Bioorg Med Chem Lett 22:1510-9 (2012) [PubMed]  Article 
Target
Name:
Bifunctional protein GlmU
Synonyms:
GLMU_STRPN | Glucosamine-1-phosphate N-acetyltransferase | N-acetylglucosamine-1-phosphate uridyltransferase | UDP-N-acetylglucosamine pyrophosphorylase | glmU
Type:
PROTEIN
Mol. Mass.:
49335.99
Organism:
Streptococcus pneumoniae
Description:
ChEMBL_804877
Residue:
459
Sequence:
MSNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQPEKTVTVVGHKAELVEEVLAGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAGDTPLITGESLKNLIDFHINHKNVATILTAETDNPFGYGRIVRNDNAEVLRIVEQKDATDFEKQIKEINTGTYVFDNERLFEALKNINTNNAQGEYYITDVIGIFRETGEKVGAYTLKDFDESLGVNDRVALATAESVMRRRINHKHMVNGVSFVNPEATYIDIDVEIASEVQIEANVTLKGQTKIGAETVLTNGTYVVDSTIGAGAVITNSMIEESSVADGVIVGPYAHIRPNSSLGAQVHIGNFVEVKGSSIGENTKAGHLTYIGNCEVGSNVNFGAGTITVNYDGKNKYKTVIGNNVFVGSNSTIIAPVELGDNSLVGAGSTITKDVPADAIAIGRGRQINKDEYATRLPHHPKNQ
  
Inhibitor
Name:
BDBM50365095
Synonyms:
CHEMBL1951184
Type:
Small organic molecule
Emp. Form.:
C29H37N3O11S
Mol. Mass.:
635.683
SMILES:
COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)NCc1ccccc1N1CCC(COC(=O)CCC(O)=O)CC1
Structure:
Search PDB for entries with ligand similarity: