Target
Squalene synthase
Ligand
BDBM50281603
Substrate
n/a
Meas. Tech.
ChEMBL_202266 (CHEMBL813379)
Ki
37±n/a nM
Citation
 Biller, SAAbt, JWPudzianowski, ATRich, LCSlusarchyk, DACiosek, C Aromatic isosteres as conformational probes for an isoprenyl subunit: application to inhibitors of squalene synthase Bioorg Med Chem Lett 3:595-600 (1993)    Article 
Target
Name:
Squalene synthase
Synonyms:
FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48109.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1336736
Residue:
416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
  
Inhibitor
Name:
BDBM50281603
Synonyms:
[Hydroxy-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyloxymethyl)-phosphinoylmethyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C17H29O6P2
Mol. Mass.:
391.3577
SMILES:
[#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#8]-[#6]P([#8-])(=O)[#6]P([#8-])([#8-])=O
Structure:
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