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Target
Gastrin-releasing peptide receptor
Ligand
BDBM50288242
Substrate
n/a
Meas. Tech.
ChEBML_71531
Ki
>10000±n/a nM
Citation
 Eden, J; Hall, M; Higginbottom, M; Horwell, D; Howson, W; Hughes, J; Jordan, R; Lewthwaite, R; Martin, K; McKnight, A; Pinnock, R; Pritchard, M; Suman-Chauhan, N; Williams, S PD 165929 the first high affinity non-peptide neuromedin-B (NMB) receptor selective antagonist Bioorg Med Chem Lett 6:2617-2622 (1996)    Article 
Target
Name:
Gastrin-releasing peptide receptor
Synonyms:
Bombesin 2 | GRP-R | GRP-preferring bombesin receptor | GRPR | GRPR_HUMAN | Gastrin releasing peptide receptor | Gastrin-releasing peptide receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43214.53
Organism:
Homo sapiens (Human)
Description:
Bombesin 2 GRPR 0::P30550
Residue:
384
Sequence:
MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV
  
Inhibitor
Name:
BDBM50288242
Synonyms:
2-[3-(2,6-Diisopropyl-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-phenethyl-propionamide | CHEMBL313829
Type:
Small organic molecule
Emp. Form.:
C33H40N4O2
Mol. Mass.:
524.6963
SMILES:
CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1
Structure:
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