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Target
D(2) dopamine receptor
Ligand
BDBM50290207
Substrate
n/a
Meas. Tech.
ChEBML_58455
Ki
15±n/a nM
Citation
 Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett 7:2403-2408 (1997)    Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50290207
Synonyms:
CHEMBL310204 | Cyclohexanecarboxylic acid (4-{2-[4-(2-chloro-phenyl)-piperazin-1-yl]-ethyl}-cyclohexyl)-amide
Type:
Small organic molecule
Emp. Form.:
C25H38ClN3O
Mol. Mass.:
432.042
SMILES:
Clc1ccccc1N1CCN(CC[C@H]2CC[C@@H](CC2)NC(=O)C2CCCCC2)CC1 |wU:13.13,wD:16.20,(14.61,-3.57,;15.7,-4.67,;17.23,-4.63,;18.04,-5.95,;17.3,-7.3,;15.76,-7.33,;14.96,-6,;13.42,-6.04,;12.69,-7.38,;11.15,-7.4,;10.34,-6.1,;8.8,-6.14,;8.05,-7.47,;6.51,-7.47,;5.72,-8.8,;4.18,-8.82,;3.43,-7.47,;4.18,-6.16,;5.72,-6.14,;1.89,-7.5,;1.12,-8.83,;-.42,-8.83,;1.89,-10.16,;1.12,-11.48,;1.87,-12.79,;3.41,-12.79,;4.18,-11.48,;3.41,-10.15,;11.09,-4.76,;12.63,-4.72,)|
Structure:
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