Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50290233
Substrate
n/a
Meas. Tech.
ChEBML_58772
Ki
5.2±n/a nM
Citation
 Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett 7:2403-2408 (1997)    Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50290233
Synonyms:
CHEMBL80615 | Cyclohexanecarboxylic acid (4-{2-[4-(3,4-dimethyl-phenyl)-piperazin-1-yl]-ethyl}-cyclohexyl)-amide
Type:
Small organic molecule
Emp. Form.:
C27H43N3O
Mol. Mass.:
425.6498
SMILES:
Cc1ccc(cc1C)N1CCN(CC[C@H]2CC[C@@H](CC2)NC(=O)C2CCCCC2)CC1 |wU:14.14,wD:17.21,(19.37,-5.49,;17.82,-5.53,;17.08,-6.88,;15.53,-6.91,;14.74,-5.59,;15.48,-4.24,;17.01,-4.19,;17.75,-2.84,;13.2,-5.62,;12.46,-6.95,;10.92,-6.99,;10.11,-5.68,;8.57,-5.71,;7.81,-7.05,;6.27,-7.06,;5.48,-8.39,;3.94,-8.4,;3.18,-7.07,;3.94,-5.74,;5.48,-5.73,;1.64,-7.07,;.87,-8.4,;-.68,-8.42,;1.64,-9.73,;.87,-11.07,;1.62,-12.39,;3.16,-12.39,;3.93,-11.07,;3.16,-9.73,;10.86,-4.33,;12.4,-4.3,)|
Structure:
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