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Target
Cathepsin D
Ligand
BDBM50071554
Substrate
n/a
Meas. Tech.
ChEMBL_45324 (CHEMBL661012)
Ki
50±n/a nM
Citation
 Carroll, CD; Patel, H; Johnson, TO; Guo, T; Orlowski, M; He, ZM; Cavallaro, CL; Guo, J; Oksman, A; Gluzman, IY; Connelly, J; Chelsky, D; Goldberg, DE; Dolle, RE Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett 8:2315-20 (1999) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM50071554
Synonyms:
3-Hydroxy-4-[(2S,3S)-3-methyl-2-(2-naphthalen-2-yl-acetylamino)-pentanoylamino]-5-phenyl-pentanoic acid butylamide | CHEMBL309721
Type:
Small organic molecule
Emp. Form.:
C33H43N3O4
Mol. Mass.:
545.7122
SMILES:
CCCCNC(=O)CC(O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)Cc1ccc2ccccc2c1)[C@@H](C)CC
Structure:
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