Reaction Details Report a problem with these data
Target
Cathepsin D
Ligand
BDBM50071559
Substrate
n/a
Meas. Tech.
ChEMBL_45324 (CHEMBL661012)
Ki
200±n/a nM
Citation
Carroll, CD; Patel, H; Johnson, TO; Guo, T; Orlowski, M; He, ZM; Cavallaro, CL; Guo, J; Oksman, A; Gluzman, IY; Connelly, J; Chelsky, D; Goldberg, DE; Dolle, RE Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett 8:2315-20 (1999) [PubMed] Article
More Info.:
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
Inhibitor
Name:
BDBM50071559
Synonyms:
(S)-2-[2-(Naphthalen-2-yloxy)-acetylamino]-pentanedioic acid 5-amide 1-[(1-benzyl-3-butylcarbamoyl-2-hydroxy-propyl)-amide] | CHEMBL73919
Type:
Small organic molecule
Emp. Form.:
C32H40N4O6
Mol. Mass.:
576.6832
SMILES:
CCCCNC(=O)CC(O)C(Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)COc1ccc2ccccc2c1