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Target
Cyclin-dependent kinase 1
Ligand
BDBM50073778
Substrate
n/a
Meas. Tech.
ChEBML_50317
IC50
550±n/a nM
Citation
 Imbach, P; Capraro, HG; Furet, P; Mett, H; Meyer, T; Zimmermann, J 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors. Bioorg Med Chem Lett 9:91-6 (1999) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM50073778
Synonyms:
CHEMBL368743 | N*2*-(2-Amino-ethyl)-9-ethyl-N*6*-(4-methoxy-phenyl)-9H-purine-2,6-diamine
Type:
Small organic molecule
Emp. Form.:
C16H21N7O
Mol. Mass.:
327.3842
SMILES:
CCn1cnc2c(Nc3ccc(OC)cc3)nc(NCCN)nc12
Structure:
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