Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50019443
Substrate
n/a
Meas. Tech.
ChEMBL_941 (CHEMBL616120)
Ki
24±n/a nM
Citation
 van Niel, MB; Beer, MS; Castro, JL; Cheng, SK; Evans, DC; Heald, A; Hitzel, L; Hunt, P; Mortishire-Smith, R; O'Connor, D; Watt, AP; MacLeod, AM Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands. Bioorg Med Chem Lett 9:3243-8 (1999) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50019443
Synonyms:
1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol | 1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol((-)-Pindolol) | 1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol(pindolol) | 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol | LB-46 | PINDOLOL | PINDOLOL,(-) | PRINODOLOL | VISKAZIDE | VISKEN
Type:
Small organic molecule
Emp. Form.:
C14H20N2O2
Mol. Mass.:
248.3208
SMILES:
CC(C)NCC(O)COc1cccc2[nH]ccc12
Structure:
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