Reaction Details Report a problem with these data
Target
Vacuolar proton pump subunit B
Ligand
BDBM50086850
Substrate
n/a
Meas. Tech.
ChEBML_148285
IC50
1500±n/a nM
Citation
Edvinsson, KM; Herslöf, M; Holm, P; Kann, N; Keeling, DJ; Mattsson, JP; Nordén, B; Shcherbukhin, V Solid phase synthesis of diamides as potential bone resorption inhibitors. Bioorg Med Chem Lett 10:503-7 (2000) [PubMed] Article
More Info.:
Target
Name:
Vacuolar proton pump subunit B
Synonyms:
Adenosinetriphosphatase | Uncharacterized protein | Vacuolar H-ATPase B subunit osteoclast isozyme
Type:
PROTEIN
Mol. Mass.:
55043.78
Organism:
Gallus gallus
Description:
ChEMBL_148284
Residue:
496
Sequence:
RRMVNGAGPGGAREQAAALTRDFLSQPRLTYKTVSGVNGPLVILDQVKFPRYAEIVHLTLPDGTRRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPAVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVMDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFEKNFIAQGPYENRTVYETLDIGWQLLRIFPKEMLKRIPQTTLAEFYPRDSTAKH
Inhibitor
Name:
BDBM50086850
Synonyms:
(2E,4E)-Hexa-2,4-dienedioic acid (3,4-dichloro-phenyl)-amide (2,2,6,6-tetramethyl-piperidin-4-yl)-amide | CHEMBL148720
Type:
Small organic molecule
Emp. Form.:
C21H27Cl2N3O2
Mol. Mass.:
424.364
SMILES:
CC1(C)CC(CC(C)(C)N1)NC(=O)\C=C\C=C\C(=O)Nc1ccc(Cl)c(Cl)c1