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Target
Matrilysin
Ligand
BDBM50098914
Substrate
n/a
Meas. Tech.
ChEBML_104910
IC50
737±n/a nM
Citation
 Pikul, S; Dunham, KM; Almstead, NG; De, B; Natchus, MG; Taiwo, YO; Williams, LE; Hynd, BA; Hsieh, LC; Janusz, MJ; Gu, F; Mieling, GE Heterocycle-based MMP inhibitors with P2' substituents. Bioorg Med Chem Lett 11:1009-13 (2001) [PubMed]  Article 
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
  
Inhibitor
Name:
BDBM50098914
Synonyms:
(R)-5-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-[1,4]diazepane-1-carboxylic acid benzyl ester | CHEMBL267939
Type:
Small organic molecule
Emp. Form.:
C21H25N3O7S
Mol. Mass.:
463.504
SMILES:
COc1ccc(cc1)S(=O)(=O)N1CCN(CC[C@@H]1C(=O)NO)C(=O)OCc1ccccc1
Structure:
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