Target
Tubulin beta-2B chain
Ligand
BDBM50109351
Substrate
n/a
Meas. Tech.
ChEMBL_211170 (CHEMBL817535)
IC50
3400±n/a nM
Citation
 Li, QWoods, KWClaiborne, AGwaltney, SLBarr, KJLiu, GGehrke, LCredo, RBHui, YHLee, JWarner, RBKovar, PNukkala, MAZielinski, NATahir, SKFitzgerald, MKim, KHMarsh, KFrost, DNg, SCRosenberg, SSham, HL Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent. Bioorg Med Chem Lett 12:465-9 (2002) [PubMed]  Article 
Target
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Inhibitor
Name:
BDBM50109351
Synonyms:
1-[5-(4-Amino-3-methyl-phenyl)-2-(3,4,5-trimethoxy-phenyl)-[1,3,4]oxadiazol-3-yl]-ethanone | A-105972 | CHEMBL136780
Type:
Small organic molecule
Emp. Form.:
C20H23N3O5
Mol. Mass.:
385.4137
SMILES:
COc1cc(cc(OC)c1OC)C1OC(=NN1C(C)=O)c1ccc(N)c(C)c1 |c:15|
Structure:
Search PDB for entries with ligand similarity: