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Target
Mu-type opioid receptor
Ligand
BDBM50027507
Substrate
n/a
Meas. Tech.
ChEMBL_148372 (CHEMBL757367)
IC50
475±n/a nM
Citation
 DiMaio, J; Nguyen, TM; Lemieux, C; Schiller, PW Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. J Med Chem 25:1432-8 (1983) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50027507
Synonyms:
Acetate1-(6-benzyl-3-isobutyl-2,5,8,11-tetraoxo-1,4,7,10tetraaza-cyclopentadec-12-ylcarbamoyl)-2-(4-hydroxy-phenyl)-ethyl-ammonium; | CHEMBL2372201
Type:
Small organic molecule
Emp. Form.:
C33H46N6O8
Mol. Mass.:
654.7537
SMILES:
CC(O)=O.CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](CCCNC1=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 |r|
Structure:
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