Reaction Details Report a problem with these data
Target
Thymidine kinase, cytosolic
Ligand
BDBM50028592
Substrate
n/a
Meas. Tech.
ChEMBL_208200 (CHEMBL878648)
Ki
2100000±n/a nM
Citation
 Hampton, A; Chawla, RR; Kappler, F Species- or isozyme-specific enzyme inhibitors. 5. Differential effects of thymidine substituents on affinity for rat thymidine kinase isozymes. J Med Chem 25:644-9 (1982) [PubMed]  Article 
Target
Name:
Thymidine kinase, cytosolic
Synonyms:
KITH_RAT | Thymidine kinase | Tk-1 | Tk1
Type:
PROTEIN
Mol. Mass.:
13514.16
Organism:
Rattus norvegicus
Description:
ChEMBL_208200
Residue:
121
Sequence:
MSYINLPTVLPISPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSNSFSTHDRNTMDALPACMLKDVAQEALGVAVIGIDEGQFFPDIVDFCETMANTGKTVIV
  
Inhibitor
Name:
BDBM50028592
Synonyms:
4-Amino-1-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidin-2-one | CHEMBL1234242
Type:
Small organic molecule
Emp. Form.:
C10H15N3O4
Mol. Mass.:
241.2438
SMILES:
Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)nc1N |r|
Structure:
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