Reaction Details Report a problem with these data
Target
Aromatase
Ligand
BDBM50024486
Substrate
n/a
Meas. Tech.
ChEBML_51214
EC50
>2000±n/a nM
Citation
 Taylor, HM; Jones, CD; Davenport, JD; Hirsch, KS; Kress, TJ; Weaver, D Aromatase inhibition by 5-substituted pyrimidines and dihydropyrimidines. J Med Chem 30:1359-65 (1987) [PubMed]  Article 
Target
Name:
Aromatase
Synonyms:
Arom | Aromatase | CP19A_RAT | CYPXIX | Cyp19 | Cyp19a1 | Cytochrome P450 19A1 | Estrogen synthetase | P-450AROM
Type:
PROTEIN
Mol. Mass.:
58418.09
Organism:
Rattus norvegicus
Description:
ChEMBL_51211
Residue:
508
Sequence:
MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESSSSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMVHVMKHSNYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTDNSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQGYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNLKVVENFINESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLHLDEDSPIVEIIFRHIFNTPFLQCLYISL
  
Inhibitor
Name:
BDBM50024486
Synonyms:
Bis-(4-chloro-phenyl)-(1-oxy-pyrimidin-5-yl)-methanol | CHEMBL29867
Type:
Small organic molecule
Emp. Form.:
C17H12Cl2N2O2
Mol. Mass.:
347.195
SMILES:
OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cnc[n+]([O-])c1
Structure:
Search PDB for entries with ligand similarity: