Target
Dihydrofolate reductase
Ligand
BDBM50367343
Substrate
n/a
Meas. Tech.
ChEMBL_54409 (CHEMBL667167)
pH
7±n/a
Temperature
298.15±n/a K
Kd
4800±n/a nM
Citation
 Taira, KBenkovic, SJ Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase. J Med Chem 31:129-37 (1988) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
Dihydrofolate reductase (F31V) | dfrA17
Type:
n/a
Mol. Mass.:
17532.46
Organism:
Escherichia coli
Description:
n/a
Residue:
157
Sequence:
MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHVEVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
  
Inhibitor
Name:
BDBM50367343
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid | FOLIC ACID | Folacin | Folvite | Vitamin B9 | Vitamin M
Type:
Small organic molecule
Emp. Form.:
C19H19N7O6
Mol. Mass.:
441.3975
SMILES:
Nc1nc2ncc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)nc2c(=O)[nH]1 |r|
Structure:
Search PDB for entries with ligand similarity: