Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50020126
Substrate
n/a
Meas. Tech.
ChEBML_1423
Ki
19±n/a nM
Citation
 Abou-Gharbia, M; Patel, UR; Webb, MB; Moyer, JA; Andree, TH; Muth, EA Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies. J Med Chem 31:1382-92 (1988) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50020126
Synonyms:
4-{4-[4-(3-chlorophenyl)hexahydro-1-pyrazinyl]butyl}-4-azatetracyclo[5.4.2.02,6.08,11]tridec-12-ene-3,5-dione;Hydrochloride | CHEMBL418762
Type:
Small organic molecule
Emp. Form.:
C26H32ClN3O2
Mol. Mass.:
454.004
SMILES:
Clc1cccc(c1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CCC43)C2=O)CC1 |c:22,(26.79,-15.91,;25.45,-16.69,;25.45,-18.23,;24.13,-19,;22.79,-18.23,;22.81,-16.69,;24.14,-15.92,;21.47,-15.91,;20.13,-16.68,;18.81,-15.91,;18.81,-14.37,;17.5,-13.6,;16.15,-14.37,;14.82,-13.6,;13.49,-14.37,;12.16,-13.6,;11.98,-12.07,;13.13,-11.05,;10.49,-11.75,;9.7,-13.1,;8.16,-13.1,;9.48,-12.33,;8.38,-11.24,;9.72,-10.41,;8.16,-10.43,;6.81,-9.66,;6.04,-10.98,;7.39,-11.75,;10.73,-14.22,;10.43,-15.73,;20.15,-13.6,;21.47,-14.37,)|
Structure:
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