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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50016549
Substrate
n/a
Meas. Tech.
ChEBML_32099
IC50
1800±n/a nM
Citation
 DeRuiter, J; Borne, RF; Mayfield, CA N- and 2-substituted N-(phenylsulfonyl)glycines as inhibitors of rat lens aldose reductase. J Med Chem 32:145-51 (1989) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50016549
Synonyms:
CHEMBL37072 | [(4-Methoxy-benzenesulfonyl)-phenyl-amino]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C15H15NO5S
Mol. Mass.:
321.348
SMILES:
COc1ccc(cc1)S(=O)(=O)N(CC(O)=O)c1ccccc1
Structure:
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