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Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50018237
Substrate
n/a
Meas. Tech.
ChEBML_152590
Ki
8±n/a nM
Citation
 Girard, GR; Bondinell, WE; Hillegass, LM; Holden, KG; Pendleton, RG; Uzinskas, I Tetrahydrothiadiazoloisoquinolines: synthesis and inhibition of phenylethanolamine-N-methyltransferase. J Med Chem 32:1566-71 (1989) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50018237
Synonyms:
6,7,8,9-Tetrahydro-3-thia-1,2,8-triaza-cyclopenta[a]naphthalene; hydrochloride | CHEMBL541538
Type:
Small organic molecule
Emp. Form.:
C9H9N3S
Mol. Mass.:
191.253
SMILES:
C1Cc2ccc3snnc3c2CN1
Structure:
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