Reaction Details Report a problem with these data
Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50007917
Substrate
n/a
Meas. Tech.
ChEBML_47834
IC50
1900±n/a nM
Citation
 Shiosaki, K; Lin, CW; Kopecka, H; Craig, R; Wagenaar, FL; Bianchi, B; Miller, T; Witte, D; Nadzan, AM Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. J Med Chem 33:2950-2 (1990) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48445.79
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-2 receptors in HEK 293 cells.
Residue:
447
Sequence:
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50007917
Synonyms:
3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indolyl)ethylcarboxamido]-5-formamidometa-methyl phenylaminopentylcarboxamido}-3-(1-carbamoyl-2-phenylethylcarbamoyl)propanoic acid | CHEMBL98468
Type:
Small organic molecule
Emp. Form.:
C43H54N8O9
Mol. Mass.:
826.9371
SMILES:
Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1
Structure:
Search PDB for entries with ligand similarity: