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TargetDopamine D2 receptor/Serotonin 2 (5-HT2) receptor
LigandBDBM50010644
Substrate/Competitorn/a
Meas. Tech.ChEBML_61432
IC50 1.9±n/a nM
Citation Högberg, TBengtsson, Sde Paulis, TJohansson, LStröm, PHall, HOgren, SO Potential antipsychotic agents 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds. J Med Chem33:1155-63 (1990) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
Name:Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
Synonyms:DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DOPAMINE D2/D4 | DRD2 | Dopamine D2 receptor | Dopamine2-like
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:50931.60
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat striatal membranes.
Residue:444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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  Blast E-value cutoff:
BDBM50010644
NameBDBM50010644
Synonyms:(S)-3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,5-dihydroxy-6-methoxy-benzamide; hydrochloride | CHEMBL3085403
TypeSmall organic molecule
Emp. Form.C15H22BrClN2O4
Mol. Mass.409.703
SMILESCl.CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)cc(O)c1OC |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a