Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50012764
Substrate
n/a
Meas. Tech.
ChEBML_31763
IC50
25±n/a nM
Citation
 Sarges, RGoldstein, SWWelch, WMSwindell, ACSiegel, TWBeyer, TA Spiro hydantoin aldose reductase inhibitors derived from 8-aza-4-chromanones. J Med Chem 33:1859-65 (1990) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50012764
Synonyms:
(+/-)-6'-chloro-2'-methyl-(2'R,4'S)-spiro[1H,2H-imidazole-4,4'-(3',4'-dihydro-2'H-pyrano[2,3-b]pyridine)]-2,5-dione | CHEMBL56453
Type:
Small organic molecule
Emp. Form.:
C11H10ClN3O3
Mol. Mass.:
267.668
SMILES:
C[C@@H]1C[C@]2(NC(=O)NC2=O)c2cc(Cl)cnc2O1
Structure:
Search PDB for entries with ligand similarity: