Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50010785
Substrate
n/a
Meas. Tech.
ChEBML_201720
IC50
203±n/a nM
Citation
 Scherz, MWFialeix, MFischer, JBReddy, NLServer, ACSonders, MSTester, BCWeber, EWong, STKeana, JF Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogues, high-affinity ligands for the haloperidol-sensitive sigma receptor. J Med Chem 33:2421-9 (1990) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50010785
Synonyms:
CHEMBL543839 | N,N'-Di-adamantan-2-yl-guanidine; hydrochloride
Type:
Small organic molecule
Emp. Form.:
C21H33N3
Mol. Mass.:
327.5068
SMILES:
NC(NC1C2CC3CC(C2)CC1C3)=NC1C2CC3CC(C2)CC1C3 |w:13.16,TLB:12:11:9:6.5.7,16:17:14.15.20:21,THB:12:6:9:3.11.10,18:19:14:17.16.23,18:17:14:19.20.21,7:6:3:8.9.10,7:8:3:6.5.12,2:3:9:6.5.7,16:15:21:17.23.18,TEB:13:14:17.16.23:19.20.21,13:14:23:19.21.18,13:14:21:17.23.18,(15.82,-2.73,;15.82,-4.29,;17.17,-5.06,;18.51,-4.29,;18.64,-2.76,;20.16,-2.28,;21.65,-2.93,;20.81,-1.76,;19.37,-2.21,;17.78,-1.44,;19.29,-3.64,;20.03,-4.87,;21.52,-4.45,;14.48,-5.06,;13.13,-4.29,;14.16,-2.99,;14.17,-1.46,;12.74,-.87,;11.4,-1.36,;11.41,-2.85,;12.74,-3.35,;10.2,-4.15,;11.71,-3.7,;11.71,-2.12,)|
Structure:
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