Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50010283
Substrate
n/a
Meas. Tech.
ChEMBL_92451 (CHEMBL878705)
IC50
5±n/a nM
Citation
 DuPriest, MTGriffin, BWKuzmich, DMcNatt, LG Spiro[fluoreneisothiazolidin]one dioxides: new aldose reductase and L-hexonate dehydrogenase inhibitors. J Med Chem 34:3229-34 (1991) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50010283
Synonyms:
2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H-imidazole)]-2',5'-dione | 2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H-imidazole)]-2',5'-dione(imirestat) | CHEMBL269455 | Imirestat
Type:
Small organic molecule
Emp. Form.:
C15H8F2N2O2
Mol. Mass.:
286.233
SMILES:
Fc1ccc2-c3ccc(F)cc3C3(NC(=O)NC3=O)c2c1
Structure:
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