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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50011394
Substrate
n/a
Meas. Tech.
ChEBML_49348
IC50
5600±n/a nM
Citation
 Kline, RH; Wright, J; Eshleman, AJ; Fox, KM; Eldefrawi, ME Synthesis of 3-carbamoylecgonine methyl ester analogues as inhibitors of cocaine binding and dopamine uptake. J Med Chem 34:702-5 (1991) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
Dopamine transporter | SC6A3_BOVIN | SLC6A3 | Sodium-dependent dopamine transporter
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75707.43
Organism:
BOVINE
Description:
Dopamine Transporter SLC6A3 BOVINE::P27922
Residue:
693
Sequence:
MSEGRCSVAHMSSVVAPAKEANAMGPKAVELVLVKEQNGVQLTNSTLLNPPQSPTEAQDRETWSKKADFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLFFMVVAGVPLFYMELALGQFNREGAAGVWKICPILRGVGYTAILISLYIGFFYNVIIAWALHYLLSSFTTELPWTHCNHSWNSPRCSDARAPNASSGPNGTSRTTPAAEYFERGVLHLHESQGIDDLGPPRWQLTSCLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLFALLLRGITLPGAVDAIRAYLSVDFHRLCEASVWIDAAIQICFSLGVGLGVLIAFSSYNKFTNNCYRDAIITTSVNSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEALATLPLSSVWAVVFFVMLLTLGIDSAMGGMESVITGLADEFQLLHRHRELFTLLVVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLMEVIGVAWFYGVWQFSDDIKQMTGRRPSLYWRLCWKFVSPCFLLFVVVVSIATFRPPHYGAYVFPEWATALGWAIAASSMSVVPIYAAYKLCSLPGSSREKLAYAITPETEHGRVDSGGGAPVHAPPLARGVGRWRKRKSCWVPSRGPGRGGPPTPSPRLAGHTRAFPWTGAPPVPRELTPPSTCRCVPPLVCAHPAVESTGLCSVY
  
Inhibitor
Name:
BDBM50011394
Synonyms:
8-Methyl-3-phenylcarbamoyloxy-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | CHEMBL164409
Type:
Small organic molecule
Emp. Form.:
C17H22N2O4
Mol. Mass.:
318.3676
SMILES:
COC(=O)C1C2CC[C@H](C[C@@H]1OC(=O)Nc1ccccc1)N2C |TLB:11:10:21:6.7,22:21:4.10.9:6.7,THB:2:4:21:6.7|
Structure:
Search PDB for entries with ligand similarity: