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TargetAldose reductase (AR)
LigandBDBM50009830
Substrate/Competitorn/a
Meas. Tech.ChEMBL_31772
IC50 440±n/a nM
Citation Mylari, BLBeyer, TASiegel, TW A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners. J Med Chem34:1011-8 (1991) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldose reductase (AR)
Name:Aldose reductase
Synonyms:AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase
Type:Protein
Mol. Mass.:35855.50
Organism:Homo sapiens (Human)
Description:P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50009830
NameBDBM50009830
Synonyms:4-Hydroxy-5-oxo-1-pyridin-2-ylmethyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester | CHEMBL6828
TypeSmall organic molecule
Emp. Form.C13H14N2O4
Mol. Mass.262.2613
SMILESCCOC(=O)C1CN(Cc2ccccn2)C(=O)C1=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a