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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50009848
Substrate
n/a
Meas. Tech.
ChEMBL_31772 (CHEMBL643099)
IC50
840±n/a nM
Citation
 Mylari, BL; Beyer, TA; Siegel, TW A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners. J Med Chem 34:1011-8 (1991) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50009848
Synonyms:
4-Hydroxy-5-oxo-1-(1-phenyl-ethyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester | CHEMBL269089
Type:
Small organic molecule
Emp. Form.:
C15H17NO4
Mol. Mass.:
275.2998
SMILES:
CCOC(=O)C1CN([C@H](C)c2ccccc2)C(=O)C1=O
Structure:
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