Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50009847
Substrate
n/a
Meas. Tech.
ChEMBL_32093 (CHEMBL644296)
IC50
910±n/a nM
Citation
 Mylari, BL; Beyer, TA; Siegel, TW A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners. J Med Chem 34:1011-8 (1991) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50009847
Synonyms:
CHEMBL428672 | ethyl 6-fluoro-4',5'-dioxospiro[3,4-dihydro-2H-chromene-4,2'-(tetrahydro-1'H-pyrrole)]-3'-carboxylate
Type:
Small organic molecule
Emp. Form.:
C15H14FNO5
Mol. Mass.:
307.2738
SMILES:
CCOC(=O)C1C(=O)C(=O)NC11CCOc2ccc(F)cc12
Structure:
Search PDB for entries with ligand similarity: