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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50007481
Substrate
n/a
Meas. Tech.
ChEBML_201890
IC50
1100±n/a nM
Citation
 Hrib, NJ; Jurcak, JG; Huger, FP; Errico, CL; Dunn, RW Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents. J Med Chem 34:1068-72 (1991) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50007481
Synonyms:
8-[3-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-propoxy]-8-aza-spiro[4.5]decane-7,9-dione(HCl0.5H2O) | CHEMBL276175
Type:
Small organic molecule
Emp. Form.:
C23H30N4O3S
Mol. Mass.:
442.574
SMILES:
O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(CC1)c1nsc2ccccc12
Structure:
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