Target
Gamma-aminobutyric acid type B receptor subunit 1/2
Ligand
BDBM50009133
Substrate
n/a
Meas. Tech.
ChEMBL_68555 (CHEMBL679479)
IC50
>100000±n/a nM
Citation
 Mann, ABoulanger, TBrandau, BDurant, FEvrard, GHeaulme, MDesaulles, EWermuth, CG Synthesis and biochemical evaluation of baclofen analogues locked in the baclofen solid-state conformation. J Med Chem 34:1307-13 (1991) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid type B receptor subunit 1/2
Synonyms:
GABA B receptor | GABA-B receptor 1/2
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 68556
Components:
This complex has 2 components.
Component 1
Name:
Gamma-aminobutyric acid type B receptor subunit 1
Synonyms:
GABA B | GABA B receptor | GABA uptake | GABA-B receptor 1 | GABA-B-R1 | GABA-BR1 | GABABR1 | GABR1_RAT | Gabbr1 | Gb1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
111548.69
Organism:
Rattus norvegicus (Rat)
Description:
Q9Z0U4
Residue:
991
Sequence:
MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSDVQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
  
Component 2
Name:
Gamma-aminobutyric acid type B receptor subunit 2
Synonyms:
GABA B receptor | GABR2_RAT | Gabbr2 | Gpr51
Type:
PROTEIN
Mol. Mass.:
105775.46
Organism:
Rattus norvegicus
Description:
O88871
Residue:
940
Sequence:
MASPPSSGQPRPPPPPPPPARLLLPLLLSLLLWLAPGAWGWTRGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWYEPAWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQFEREYNSKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGKIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILSLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
  
Inhibitor
Name:
BDBM50009133
Synonyms:
4-Amino-3-(2,6-dichloro-phenyl)-butyric acid; hydrochloride | CHEMBL543270
Type:
Small organic molecule
Emp. Form.:
C10H11Cl2NO2
Mol. Mass.:
248.106
SMILES:
NCC(CC(O)=O)c1c(Cl)cccc1Cl
Structure:
Search PDB for entries with ligand similarity: