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TargetNeurokinin 1 receptor
LigandBDBM50009223
Substrate/Competitorn/a
Meas. Tech.ChEMBL_208655
IC50 2600±n/a nM
Citation Appell, KCBabb, BEGoswami, RHall, PLLawrence, KBLogan, MEPrzyklek-Elling, RTomczuk, BEVenepalli, BRYanni, JM Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists. J Med Chem34:1751-3 (1991) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neurokinin 1 receptor
Name:Neurokinin 1 receptor
Synonyms:NK-1 receptor | NK-1R | NK1 Receptor | Neurokinin NK1 | SPR | Substance-P receptor | TACR1 | Tachykinin receptor 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46371.54
Organism:Rattus norvegicus (rat)
Description:Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor.
Residue:407
Sequence:
MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAH
KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTIST
VVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50009223
NameBDBM50009223
Synonyms:2-[3-(1-Dimethylcarbamoylmethyl-3,3-dimethyl-1,3-dihydro-indol-2-ylidene)-propenyl]-1,3-diethyl-3H-imidazo[4,5-b]quinoxalin-1-ium; chloride | CHEMBL52448
TypeSmall organic molecule
Emp. Form.C30H35N6O
Mol. Mass.495.638
SMILESCCn1c(\C=C\C=C2\N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc12
Structure
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