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TargetNeurokinin 1 receptor
LigandBDBM50009226
Substrate/Competitorn/a
Meas. Tech.ChEMBL_208655
IC50 390±n/a nM
Citation Appell, KCBabb, BEGoswami, RHall, PLLawrence, KBLogan, MEPrzyklek-Elling, RTomczuk, BEVenepalli, BRYanni, JM Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists. J Med Chem34:1751-3 (1991) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neurokinin 1 receptor
Name:Neurokinin 1 receptor
Synonyms:NK-1 receptor | NK-1R | NK1 Receptor | Neurokinin NK1 | SPR | Substance-P receptor | TACR1 | Tachykinin receptor 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46371.54
Organism:Rattus norvegicus (rat)
Description:Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor.
Residue:407
Sequence:
MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAH
KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTIST
VVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
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  Blast E-value cutoff:
BDBM50009226
NameBDBM50009226
Synonyms:1,3-Diethyl-2-[3-(1-ethyl-3,3-dimethyl-1,3-dihydro-indol-2-ylidene)-propenyl]-3H-imidazo[4,5-b]quinoxalin-1-ium; chloride | CHEMBL48734
TypeSmall organic molecule
Emp. Form.C28H32N5
Mol. Mass.438.5866
SMILESCCN1\C(=C\C=C\c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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