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Target
Substance-P receptor
Ligand
BDBM50009233
Substrate
n/a
Meas. Tech.
ChEMBL_208655 (CHEMBL811431)
IC50
850±n/a nM
Citation
 Appell, KC; Babb, BE; Goswami, R; Hall, PL; Lawrence, KB; Logan, ME; Przyklek-Elling, R; Tomczuk, BE; Venepalli, BR; Yanni, JM Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists. J Med Chem 34:1751-3 (1991) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R_RAT | Neurokinin 1 receptor | Neurokinin NK1 | SPR | Substance-P receptor | Tac1r | Tachykinin receptor 1 | Tacr1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46371.54
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor.
Residue:
407
Sequence:
MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
  
Inhibitor
Name:
BDBM50009233
Synonyms:
1,3-Diethyl-2-[3-(1-methyl-2a,5-dihydro-1H-benzo[cd]indol-2-ylidene)-propenyl]-3H-imidazo[4,5-b]quinoxalin-1-ium; chloride | CHEMBL52114
Type:
Small organic molecule
Emp. Form.:
C28H28N5
Mol. Mass.:
434.5549
SMILES:
CCn1c(\C=C\C=C2/C3C=CCc4cccc(N2C)c34)[n+](CC)c2nc3ccccc3nc12 |c:9|
Structure:
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