Reaction Details Report a problem with these data
Target
Adenosine deaminase
Ligand
BDBM50012528
Substrate
n/a
Meas. Tech.
ChEBML_30795
Ki
270±n/a nM
Citation
 Cristalli, G; Vittori, S; Eleuteri, A; Grifantini, M; Volpini, R; Lupidi, G; Capolongo, L; Pesenti, E Purine and 1-deazapurine ribonucleosides and deoxyribonucleosides: synthesis and biological activity. J Med Chem 34:2226-30 (1991) [PubMed]  Article 
Target
Name:
Adenosine deaminase
Synonyms:
ADA | ADA_BOVIN | Adenosine aminohydrolase
Type:
Enzyme
Mol. Mass.:
40910.44
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
363
Sequence:
MAQTPAFNKPKVELHVHLDGAIKPETILYYGRKRGIALPADTPEELQNIIGMDKPLSLPEFLAKFDYYMPAIAGCREAVKRIAYEFVEMKAKDGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVSLVNQGLQEGERDFGVKVRSILCCMRHQPSWSSEVVELCKKYREQTVVAIDLAGDETIEGSSLFPGHVKAYAEAVKSGVHRTVHAGEVGSANVVKEAVDTLKTERLGHGYHTLEDATLYNRLRQENMHFEVCPWSSYLTGAWKPDTEHPVVRFKNDQVNYSLNTDDPLIFKSTLDTDYQMTKNEMGFTEEEFKRLNINAAKSSFLPEDEKKELLDLLYKAYGMPSPASAEQCL
  
Inhibitor
Name:
BDBM50012528
Synonyms:
5-(7-Hydroxyamino-imidazo[4,5-b]pyridin-3-yl)-2-hydroxymethyl-tetrahydro-furan-3-ol | CHEMBL3142245
Type:
Small organic molecule
Emp. Form.:
C11H14N4O4
Mol. Mass.:
266.2533
SMILES:
OC[C@H]1O[C@H](C[C@@H]1O)n1cnc2c(NO)ccnc12 |r|
Structure:
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