Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50010046
Substrate
n/a
Meas. Tech.
ChEBML_61769
IC50
>1000±n/a nM
Citation
 Malleron, JL; Comte, MT; Gueremy, C; Peyronel, JF; Truchon, A; Blanchard, JC; Doble, A; Piot, O; Zundel, JL; Huon, C Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists. J Med Chem 34:2477-83 (1991) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50010046
Synonyms:
2-[3-(4-Benzothiazol-2-yl-piperazin-1-yl)-propyl]-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide | CHEMBL83391
Type:
Small organic molecule
Emp. Form.:
C24H24N4O2S2
Mol. Mass.:
464.603
SMILES:
O=S1(=O)N(CCCN2CCN(CC2)c2nc3ccccc3s2)c2cccc3cccc1c23
Structure:
Search PDB for entries with ligand similarity: