Reaction Details Report a problem with these data
Target
Cytidine deaminase
Ligand
BDBM50007156
Substrate
n/a
Meas. Tech.
ChEBML_52540
Ki
25100000±n/a nM
Citation
 Lin, TS; Luo, MZ; Liu, MC; Clarke-Katzenburg, RH; Cheng, YC; Prusoff, WH; Mancini, WR; Birnbaum, GI; Gabe, EJ; Giziewicz, J Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride. J Med Chem 34:2607-15 (1991) [PubMed]  Article 
Target
Name:
Cytidine deaminase
Synonyms:
CDA | CDD | CDD_HUMAN | Cytidine deaminase | Cytidine deaminase (CDA)
Type:
Ezyme
Mol. Mass.:
16185.04
Organism:
Homo sapiens (Human)
Description:
P32320
Residue:
146
Sequence:
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACYPLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKPDGTYIVMTVQELLPSSFGPEDLQKTQ
  
Inhibitor
Name:
BDBM50007156
Synonyms:
4-Amino-5-fluoro-1-(4-hydroxy-5-hydroxymethyl-3-methylene-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one | CHEMBL3142569
Type:
Small organic molecule
Emp. Form.:
C10H12FN3O4
Mol. Mass.:
257.2184
SMILES:
Nc1nc(=O)n(cc1F)[C@@H]1O[C@H](CO)[C@@H](O)C1=C |r|
Structure:
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