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TargetDopamine Transporter (DAT)
LigandBDBM50008060
Substrate/Competitorn/a
Meas. Tech.ChEBML_61994
IC50 3370±n/a nM
Citation Abraham, PPitner, JBLewin, AHBoja, JWKuhar, MJCarroll, FI N-modified analogues of cocaine: synthesis and inhibition of binding to the cocaine receptor. J Med Chem35:141-4 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine Transporter (DAT)
Name:Monoamine transporters; Norepininephrine & dopamine
Synonyms:DA transporter | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:Multi-pass membrane protein
Mol. Mass.:68749.45
Organism:Rattus norvegicus (rat)
Description:Rat caudate membranes were used as DAT source in binding assay.
Residue:619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50008060
NameBDBM50008060
Synonyms:8-Acetyl-3-benzoyloxy-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | CHEMBL288315
TypeSmall organic molecule
Emp. Form.C18H21NO5
Mol. Mass.331.363
SMILESCOC(=O)C1C2CC[C@H](CC1OC(=O)c1ccccc1)N2C(C)=O |TLB:11:10:20:6.7,THB:2:4:20:6.7|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a