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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50008060
Substrate
n/a
Meas. Tech.
ChEBML_61994
IC50
3370±n/a nM
Citation
 Abraham, P; Pitner, JB; Lewin, AH; Boja, JW; Kuhar, MJ; Carroll, FI N-modified analogues of cocaine: synthesis and inhibition of binding to the cocaine receptor. J Med Chem 35:141-4 (1992) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50008060
Synonyms:
8-Acetyl-3-benzoyloxy-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | CHEMBL288315
Type:
Small organic molecule
Emp. Form.:
C18H21NO5
Mol. Mass.:
331.363
SMILES:
COC(=O)C1C2CC[C@H](CC1OC(=O)c1ccccc1)N2C(C)=O |TLB:11:10:20:6.7,THB:2:4:20:6.7|
Structure:
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