Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50006496
Substrate
n/a
Meas. Tech.
ChEMBL_31761 (CHEMBL641355)
IC50
50±n/a nM
Citation
 Lipinski, CAAldinger, CEBeyer, TABordner, JBurdi, DFBussolotti, DLInskeep, PBSiegel, TW Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors. J Med Chem 35:2169-77 (1992) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50006496
Synonyms:
(7-Bromo-6-chloro-4-hydroxy-2-methyl-chroman-4-yl)-acetic acid | CHEMBL304302
Type:
Small organic molecule
Emp. Form.:
C12H12BrClO4
Mol. Mass.:
335.578
SMILES:
C[C@@H]1C[C@@](O)(CC(O)=O)c2cc(Cl)c(Br)cc2O1
Structure:
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