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TargetRenin
LigandBDBM50006857
Substrate/Competitorn/a
Meas. Tech.ChEBML_195741
IC50 3.6±n/a nM
Citation Patt, WCHamilton, HWTaylor, MDRyan, MJTaylor, DGConnolly, CJDoherty, AMKlutchko, SRSircar, ISteinbaugh, BA Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors. J Med Chem35:2562-72 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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  Blast E-value cutoff:
BDBM50006857
NameBDBM50006857
Synonyms:4-{3-(2-Amino-thiazol-4-yl)-2-[2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-propionylamino}-5-cyclohexyl-3-hydroxy-pentanoic acid {2-[bis-(2-hydroxy-ethyl)-amino]-ethyl}-amide | CHEMBL316218
TypeSmall organic molecule
Emp. Form.C36H58N8O9S2
Mol. Mass.811.024
SMILESNc1nc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NS(=O)(=O)N2CCOCC2)C(=O)N[C@@H](CC2CCCCC2)[C@@H](O)CC(=O)NCCN(CCO)CCO)cs1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a