Reaction Details Report a problem with these data
Target
Histamine H1 receptor
Ligand
BDBM74475
Substrate
n/a
Meas. Tech.
ChEMBL_218827 (CHEMBL823938)
IC50
>100000±n/a nM
Citation
Diurno, MV; Mazzoni, O; Piscopo, E; Calignano, A; Giordano, F; Bolognese, A Synthesis and antihistaminic activity of some thiazolidin-4-ones. J Med Chem 35:2910-2 (1992) [PubMed] Article
More Info.:
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1 | HRH1_CAVPO
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55641.53
Organism:
Cavia porcellus (domestic guinea pig)
Description:
Guinea pig cerebellum was used in binding assay.
Residue:
488
Sequence:
MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
Inhibitor
Name:
BDBM74475
Synonyms:
3-[3-(dimethylamino)propyl]-2-(4-methoxyphenyl)-1,3-thiazolidin-4-one hydrochloride | 3-[3-(dimethylamino)propyl]-2-(4-methoxyphenyl)-1,3-thiazolidin-4-one;hydrochloride | 3-[3-(dimethylamino)propyl]-2-(4-methoxyphenyl)-4-thiazolidinone;hydrochloride | 3-[3-(dimethylamino)propyl]-2-(4-methoxyphenyl)thiazolidin-4-one;hydrochloride | MLS000533188 | SMR000140626 | cid_2860932
Type:
Small organic molecule
Emp. Form.:
C15H22N2O2S
Mol. Mass.:
294.412
SMILES:
COc1ccc(cc1)C1SCC(=O)N1CCCN(C)C