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Target
Platelet-activating factor receptor
Ligand
BDBM50004650
Substrate
n/a
Meas. Tech.
ChEBML_162882
IC50
2.3±n/a nM
Citation
 Cooper, K; Fray, MJ; Parry, MJ; Richardson, K; Steele, J 1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives. J Med Chem 35:3115-29 (1992) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50004650
Synonyms:
6-Methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-4-(2-trifluoromethoxy-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester ( H2O) | CHEMBL323382
Type:
Small organic molecule
Emp. Form.:
C35H29F3N6O4
Mol. Mass.:
654.6378
SMILES:
CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1OC(F)(F)F)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7|
Structure:
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