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Target
Platelet-activating factor receptor
Ligand
BDBM50004648
Substrate
n/a
Meas. Tech.
ChEBML_162882
IC50
5.9±n/a nM
Citation
 Cooper, K; Fray, MJ; Parry, MJ; Richardson, K; Steele, J 1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives. J Med Chem 35:3115-29 (1992) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50004648
Synonyms:
4-(2-Chloro-phenyl)-6-methyl-5-(pyridin-2-ylcarbamoyl)-2-[4-(2,4,6-trimethyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester ( H2O) | CHEMBL322772
Type:
Small organic molecule
Emp. Form.:
C36H33ClN6O3
Mol. Mass.:
633.139
SMILES:
CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2c(C)nc(C)cc12 |t:5,7|
Structure:
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