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Target
Platelet-activating factor receptor
Ligand
BDBM50002822
Substrate
n/a
Meas. Tech.
ChEMBL_154987 (CHEMBL882497)
Ki
110±n/a nM
Citation
 Girotra, NN; Biftu, T; Ponpipom, MM; Acton, JJ; Alberts, AW; Bach, TN; Ball, RG; Bugianesi, RL; Parsons, WH; Chabala, JC Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester. J Med Chem 35:3474-82 (1992) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM50002822
Synonyms:
(-)-trans 42s,5S)-2-[3-[(2-Oxopropyl)sulfony1]-4-n-propoxy-5-[3-(phosphonooxy)propoxy]phenyl]-5-(3,4,5-trimethoxypheny1) tetrahydrofuran Monopotassium Salt | CHEMBL325491
Type:
Small organic molecule
Emp. Form.:
C28H38O13PS
Mol. Mass.:
645.633
SMILES:
CCCOc1c(OCCCOP(O)([O-])=O)cc(cc1S(=O)(=O)CC(C)=O)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
Structure:
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