Target
Substance-P receptor
Ligand
BDBM50002376
Substrate
n/a
Meas. Tech.
ChEBML_208658
IC50
>10000±n/a nM
Citation
 Venepalli, BRAimone, LDAppell, KCBell, MRDority, JAGoswami, RHall, PLKumar, VLawrence, KBLogan, ME Synthesis and substance P receptor binding activity of androstano[3,2-b]pyrimido[1,2-a]benzimidazoles. J Med Chem 35:374-8 (1992) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R_RAT | Neurokinin 1 receptor | Neurokinin NK1 | SPR | Substance-P receptor | Tac1r | Tachykinin receptor 1 | Tacr1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46371.54
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor.
Residue:
407
Sequence:
MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
  
Inhibitor
Name:
BDBM50002376
Synonyms:
4-[4,17-dihydroxy-15a,17a-dimethyl-(4R,15aS,17S,17aR)-2,3,3a,3b,4,5,5a,6,15,15a,15b,16,17,17a-tetradecahydro-1H-benzo[4,5]imidazo[2,1-b]cyclopenta[5,6]naphtho[1,2-g]quinazolin-1-yl]pentanoic acid(0.4MH2O) | CHEMBL436004
Type:
Small organic molecule
Emp. Form.:
C32H41N3O4
Mol. Mass.:
531.6856
SMILES:
CC(CCC(O)=O)[C@H]1CCC2C3[C@H](O)CC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3C[C@H](O)[C@]12C
Structure:
Search PDB for entries with ligand similarity: