Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50003247
Substrate
n/a
Meas. Tech.
ChEBML_45064
Ki
3.3±n/a nM
Citation
 Hartman, GD; Halczenko, W; Smith, RL; Sugrue, MF; Mallorga, PJ; Michelson, SR; Randall, WC; Schwam, H; Sondey, JM 4-substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors. J Med Chem 35:3822-31 (1992) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50003247
Synonyms:
4-(4-Morpholin-4-ylmethyl-benzoyl)-thiophene-2-sulfonic acid amide; hydrochloride | CHEMBL545756
Type:
Small organic molecule
Emp. Form.:
C16H18N2O4S2
Mol. Mass.:
366.455
SMILES:
NS(=O)(=O)c1cc(cs1)C(=O)c1ccc(CN2CCOCC2)cc1
Structure:
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