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Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50001269
Substrate
n/a
Meas. Tech.
ChEMBL_52046 (CHEMBL666432)
IC50
57±n/a nM
Citation
 Zamboni, R; Belley, M; Champion, E; Charette, L; DeHaven, R; Frenette, R; Gauthier, JY; Jones, TR; Leger, S; Masson, P Development of a novel series of styrylquinoline compounds as high-affinity leukotriene D4 receptor antagonists: synthetic and structure-activity studies leading to the discovery of (+-)-3-[[[3-[2-(7-chloro-2-quinolinyl)-(E)-ethenyl]phenyl][[3- (dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic J Med Chem 35:3832-44 (1992) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_CAVPO | CYSLTR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39007.58
Organism:
GUINEA PIG
Description:
Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:
340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
  
Inhibitor
Name:
BDBM50001269
Synonyms:
3-((2-Carboxy-ethylsulfanyl)-{3-[2-(7-chloro-quinolin-2-yl)-ethyl]-phenyl}-methylsulfanyl)-propionic acid | CHEMBL123623
Type:
Small organic molecule
Emp. Form.:
C24H24ClNO4S2
Mol. Mass.:
490.035
SMILES:
OC(=O)CCSC(SCCC(O)=O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1
Structure:
Search PDB for entries with ligand similarity: