Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-1
Ligand
BDBM50001556
Substrate
n/a
Meas. Tech.
ChEBML_69323
IC50
800±n/a nM
Citation
 Melikian, A; Schlewer, G; Chambon, JP; Wermuth, CG Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists. J Med Chem 35:4092-7 (1992) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-1
Synonyms:
GABA receptor alpha-1 subunit | GABA-A receptor; anion channel | GBRA1_MOUSE | Gabra-1 | Gabra1
Type:
PROTEIN
Mol. Mass.:
51770.21
Organism:
Mus musculus
Description:
ChEMBL_69323
Residue:
455
Sequence:
MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
  
Inhibitor
Name:
BDBM50001556
Synonyms:
4-(6-Imino-5-methyl-3-phenyl-6H-pyridazin-1-yl)-butyric acid | CHEMBL132561
Type:
Small organic molecule
Emp. Form.:
C15H17N3O2
Mol. Mass.:
271.3144
SMILES:
Cc1cc(nn(CCCC(O)=O)c1=N)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: